曼扭拉曼汀格林是加州大学河滨分校的细胞生物学教授。隶属于河滨大学策略交流部。
Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.
在加州大学河滨分校的研究者刚刚确定了石榴汁当中的能抑制癌细胞扩散和弱化诱导前列腺癌细胞向骨头转移的化合物。这项研究将会引发癌转移的新疗法。
Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented today (Dec. 12, 2010) at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.
今天在曼扭拉曼汀格林研究室，一个细胞生物学教授演示了实验，就在费城美国细胞生物学社会50周年纪念日的开会地点。
Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient's death.
前列腺癌是导致美国癌症男性患者死亡的第二大原因。到现在并没有一个有效的疗法可以治疗之。如果前列腺癌通过化疗或手术得到了治疗，那么下一步将会是对男性激素水平的调控治疗，凭借癌细胞需要激素生长的条件这个抑制了癌细胞的生长。不过经过一段时间后，癌细胞会产生对调控药物的抗性，变得十分好斗，并转移到骨髓、肺脏及淋巴结，通常导致了患者的死亡。
The Martins-Green lab applied pomegranate juice on laboratory-cultured prostate cancer cells that were resistant to testosterone (the more resistant a cancer cell is to testosterone, the more prone it is to metastasizing).
曼汀格林实验室在实验室培养的对调控激素药物产生抗性的前列腺癌细胞上使用了石榴汁（癌细胞对调控药物的抗性越大，其越容易转移。）
The researchers – Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho – found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.
研究者——曼汀格林，毕业生王磊和肄业生安德阿肯和杰夫丽霍－发现石榴汁治疗的肿瘤细胞并没有因此死亡，表现在更好的黏着性（意味着更少的细胞逃跑了）和减少的细胞转移量。
Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.
下一步，研究者确定了石榴汁中的对前列腺癌细胞黏着、转移起关键作用的活性成分：糖类，氨基酸，黄酮还是共轭脂肪酸。
"Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate cancer metastasis, leading to more effective drug therapies," Martins-Green said. "Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment."
“确认他们的身份了以后，我们现在能在石榴汁中修改癌抑制化合物，以提升其在抑制癌细胞转移的功能，以达到更好的药物治疗效果。”曼汀格林说：”因为参与了前列腺癌细胞的活动的特定的基因和蛋白在其他癌细胞活动中也起到了相同的作用，郭治中同样的化合物可以有在癌症治疗里更为广泛的治疗应用。“
Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.
曼汀格林结识骨髓中产生的一种重要的蛋白是导致癌细胞向其转移并产生肿瘤的重要化学物质。
"We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone," Martins-Green said.
”我们演示出石榴汁明显的抑制了这种蛋白的功能，因此这种果汁拥有抑制癌细胞向骨转移的潜能“曼汀格林如是说。
Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side effects.
下一步，她的实验室准备进行下一步的活体前列腺癌转移实验来确定是不是同样的癌抑制化合物可以抑制癌症的同时不造成副作用。